I have on other vehicles. Not the Escalade, doesn't burn a drop of oil, no leaks at 160k. I would only use it if you need to, like an oil leak, or bad valve seals. Don't use it just because of the miles. No need. And potentially once you do, its a lifetime decision. Potentially. Because it puffs up rubber to seal leaks. Once you switch away, leaks come back worse than ever. So only make the switch when you have a rubber seal or gasket issue in the engine somewhere