im sure they could handle the horsepower, but the torque is what concerns me. 385 ft/lbs, that 85 more than the northstar. Im not sure the trannys are designed for that much torque.
I think it would be great if cadillac made about 5L 12cy. I know their coming out with the XV12, which is a 5.?L V12, with variable valve timing and cylinder shut off (during highway crusing 6 cyls. turn off for fuel economy). I think if they made smaller V8s or v10s, they will keep up with the luxary market.
Ive got a vortec 5.3 in my tahoe, and it is a torque monster (cant burn too much rubber, its too heavy

).
Personally, i dont think its worth it in a new caddy. By the time you spend the time and money on the conversion, you could have more horsepower in the northstar by adding a supercharger, and other mods.
But then again thats just me....