Like Kev said they will fall apart very quickly when wet. On the 4.9 you can just stuff them down the radiator neck. If they don't fit, then crush or break them up a bit. The only reason for crushing them is because they may make contact with the trans cooler line in the radiator side tank and prevent you from pushing any more in there.
If you put them in to the radiator neck you (I did this) can disolve them in a cup of water first and then pour the spooge right down in there. Just be sure to get them directly into the cooling system, either radiator or hose, NOT in the overflow tank.