Does anybody know if the tire sensors on and 07 escalade will still work after installing them in aftermarket wheels?

Sure they will, no problem. :)

yes they will I have an 07 with 24's.

I have had it done but I have had issues. I can't figure it out but after driving for 20min they start to go hay wire.

I think it might have to do with the nitrogen. Anyone else have nitrogen in their tires?

I had nitrogen in my Corvette tires with sensors and never had a problem

I have had it done but I have had issues. I can't figure it out but after driving for 20min they start to go hay wire.

I think it might have to do with the nitrogen. Anyone else have nitrogen in their tires?

Nothing to do with Nitrogen. Your issue is that the sensors need to be retrained. Your local Cadillac Dealership, or TireShop if they have the TIPS TPMS tool can retrain your sensors. Sounds like they weren't kept in the same spot when your wheels were installed and they just need to be retrained.

They probably go bonkers because they are set to measure pressures around 35psi for the stockers. when you put them in wheel at around 45psi they don't know what to make of it and go into reset mode. They probably need to be recalibrated to the new psi range.