Bob,
I don't know much about the injection units on these. They didn't build many cars with EFI.....I believe it was an option on all 75 and 76 models but most had a carb. I don't know if there are any replacement parts available for this system but if it became a problem, a carb could be put in its place (not sure if the intake is different though). Maximum Torque Specialties sells a complete Cadillac 500 EFI system for $795 (hotrodders like them

).
The motors have a higher nickel content than most other motors thus making them physically harder and less prone to wear. My 500 (out of a '72 Eldorado) has 96,000 miles on it. I started pulling it apart for a performance rebuild. There is very little wear in the cylinders. In some cylinders you can still see the original (from the factory) hone marks.
As long as the trans shifts well, you shouldn't have a problem. The Turbo 400 was used in all sorts of different cars and trucks over the years. It was GM's heavy-duty automatic transmission.
As for gaskets and seals.....this car shouldn't give you any more problems than any other car of that age. Any seal and gasket can get brittle over time.
Hope this helps.