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Not to state the obvious, but the CTS offers rear wheel drive and the world class Sigma platform. The Lacrosse is FWD, and is based on the Opel Vectra, which is a nice enough car, and much improved over the previous edition, but it is built to a much lower price point, and is not meant to compete with CTS, BMW 3 series, etc. The original Lacrosse was the replacement for the Regal, though it looks like they're trying to move it upmarket a bit. It may have lots of nice options and gadgets, but it's basic bones are not in the same class as the CTS, nor will it be nearly as sporty to drive.